Researchers studying the relationship between kidney stones and chronic kidney disease have discovered evidence of kidney disease after the first stone event.
In a paper published online in Mayo Clinic Proceedings (Oct. 21, 2016), nephrologists revealed a persistent decline in kidney function following a patient’s initial case of kidney stones.
“Stone formers only have a transient rise in serum creatinine, but they have a sustained higher cystatin C and urine protein after the first stone event. This means that some, but not all markers of kidney function show abnormalities after the first stone event,” co-lead author Andrew Rule, MD, told Urology Times.
According to the National Kidney Foundation, kidney stones affect approximately 8.8% of adults, a number that has been rising for years. Previous studies on the subject have identified a long-term risk of chronic kidney disease in stone formers. However, prior research has not assessed kidney function immediately after a first stone event.
“We and others have known that stone formers have about twice the risk of kidney failure as controls. We wanted to know if there was any evidence of kidney disease after the first stone event. We did not expect there to be any sustained kidney function abnormalities after the first stone event because we thought kidney dysfunction would only occur after multiple stone events,” Dr. Rule said.
For the study, the authors looked at 384 first-time stone formers with study visits 90 days and 180 days after the stone event. Clinical and laboratory characteristics at visit 1 were compared between stone formers and controls using linear and logistic regression models with adjustment for age and sex. Kidney function by serum creatinine, cystatin C, 24-hour urine protein, and 24-hour urine albumin levels were compared between stone formers and controls at visits 1 and 2 using age- and sex-adjusted and multivariable-adjusted linear and logistic regression models.